Thoughtful delivery service

Easy 30 day returns

Certified Reviews

Description

MS250000: 4-Fluoro-N-AcetylglucosamineC8H14FNO5 223. 2 A fluorinated N acetylglucosamine analog in which the C4 hydroxyl is replaced by a fluorine. Fluorinated GlcNAc analogs are valuable probes for studying GlcNAc processing enzymes (O GlcNAc transferase OGA, hexosaminidases, glycosyltransferases) and as metabolic inhibitors of N glycan, O GlcNAc, and glycosaminoglycan biosynthesis. The carbon fluorine bond is stable, isosteric with the native hydroxyl, and provides a handle for F NMR

biosynthesis substrate

87 / An Fmoc-protected L-asparagine building block carrying a core-fucosylated Fucα1-6GlcNAc disaccharide

T Antigen (Serine

/ β-D-LacNAc-Ethyl-Azide / 2-Azidoethyl LacNAc

enzymatic cleavage releases 4-nitrophenol

22 / An α-D-mannose ligand equipped with an azide-functionalized linker through a short ethyl spacer

α-D-GalNAc-Bu-COOH

/ β-D-Gal-Ethyl-Amine / β-Gal-Et-NH2

2-Azidoethyl N-acetyl-α-D-galactosaminide

enzymatic cleavage of the aglycone-proximal α-glucosidic bond releases 4-nitrophenol

followed by cleavage of the α-glycosidic bond by α-L-iduronidase (IDUA) to release 4-methylumbelliferone

/ Fmoc-Ser(Galβ(1-3)(GlcNAcβ(1-6))GalNAc-OH (Peracetate) / Core 2 O-Glycan on Serine